Synthesis and Antimicrobial Activity of Some Novel 5-Alkyl-6-Substituted Uracils and Related Derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis and antimicrobial activity of some novel 5-alkyl-6-substituted uracils and related derivatives.
6-chloro-5-ethyl-, n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloro-pyrimidines 4a-c, which were selectively hydrolyzed by heating in 10% aqueous sodium hydroxide for 30 minutes. The reaction of compounds 5a-c with 1...
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ژورنال
عنوان ژورنال: Molecules
سال: 2011
ISSN: 1420-3049
DOI: 10.3390/molecules16064764